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Friday, December 9, 2022

Scientists Discover Compound That Mimics Certain Benefits of Exercise | Extreme Tech

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Locamidazole was created with the goal of preventing impaired locomotion in persons who are unable to exercise and enhancing bone fragility. In an effort to find the best course of action, the researchers created their own system for assessing the health of bone and muscle cells. They tested 296 chemical compounds using this method to see how they affected the growth and development of myocytes, osteoblasts, and osteoclasts. A total of eight substances were discovered that enhance cell differentiation and health. One of these had the ability to improve myoblast and osteoblast activity, hence promoting the formation of bone and muscle tissue. Locamidazole, or LAMZ, is the name given to this substance. The team next gave mice oral doses of LAMZ to assess the drug’s effects. The medication did not appear to have any negative side effects, but it did successfully boost bone production, maximal muscle strength, and muscle fiber width in treated mice. Additionally, it reduced the animals’ activity in bone resorption.



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