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Friday, December 9, 2022

Scientists Discover Compound That Mimics Certain Benefits of Exercise | Extreme Tech

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A chemical molecule that can duplicate some of the advantages of exercise has been discovered by researchers at Tokyo Medical and Dental University (TMDU).

 

Locamidazole was created with the goal of preventing impaired locomotion in persons who are unable to exercise and enhancing bone fragility. In an effort to find the best course of action, the researchers created their own system for assessing the health of bone and muscle cells. They tested 296 chemical compounds using this method to see how they affected the growth and development of myocytes, osteoblasts, and osteoclasts. A total of eight substances were discovered that enhance cell differentiation and health. One of these had the ability to improve myoblast and osteoblast activity, hence promoting the formation of bone and muscle tissue. Locamidazole, or LAMZ, is the name given to this substance. The team next gave mice oral doses of LAMZ to assess the drug’s effects. The medication did not appear to have any negative side effects, but it did successfully boost bone production, maximal muscle strength, and muscle fiber width in treated mice. Additionally, it reduced the animals’ activity in bone resorption. Even better, it was discovered that LAMZ mimicked the calcium and PGC-1 signaling pathways, which are normally activated during exercise and support the maintenance of bone and muscle tissue.

Source:https://www.extremetech.com/extreme/340426-scientists-discover-compound-that-mimics-certain-benefits-of-exercise

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