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The Crossroads of Special Operations

Thursday, September 16, 2021

Brain protein mutation from child with autism causes autism-like behavioral change in mice | Science Daily

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A de novo gene mutation that encodes a brain protein in a child with autism has been placed into the brains of mice. These mice then showed severe alterations of specific behaviors that closely resemble those seen in human autism spectrum disorder, or ASD.

This major finding from a study published in the Journal of Clinical Investigation “presents the exciting possibility of a potential mechanistic underpinning — in at least a subset of patients — for some of the altered behaviors observed in ASD and attention deficit hyperactivity disorder, or ADHD,” said Aurelio Galli, Ph.D., professor of surgery at the University of Alabama at Birmingham.

The research was led by corresponding authors Galli and Mark Wallace, Ph.D., a neurobiologist and dean at Vanderbilt University.

Source: Brain protein mutation from child with autism causes autism-like behavioral change in mice | Science Daily

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