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Researchers link defects in a nuclear receptor in the brain to autism spectrum disorders | Science Daily

Researchers link defects in a nuclear receptor in the brain to autism spectrum disorders | Science Daily

Two University of Houston scientists are reporting that defects in a portion of the brain’s hippocampus, called the dentate gyrus, is regulated by the nuclear receptor LXRβ (Liver X receptor Beta). The dentate gyrus, or DG, is responsible for emotion and memory and is known to be involved in autism spectrum disorders (ASD).

Margaret Warner, professor of biology and biochemistry, and Jan-Åke Gustafsson, professor of biology, biochemistry and founding director of the UH Center of Nuclear Receptors and Cell Signaling, describe the work in the Proceedings of the National Academy of Sciences.

For four decades they have worked together, making discovery after discovery about the role of nuclear receptors in brain functions, and they show no sign of slowing down.

Source: Researchers link defects in a nuclear receptor in the brain to autism spectrum disorders | Science Daily