Islamic State (IS) militants have captured al-Qaryatain town, in the province of Homs, from pro-government forces, reports say.
The militants launched the attack with suicide bombings at the town’s checkpoints, according to the Syrian Observatory for Human Rights (SOHR), a UK-based monitoring group.
It said the capture of the town links IS-held Palmyra with the Qalamun area.
Separately, the US launched its first drone strike against IS from Turkey.
A Pentagon spokesman did not give any further details about the strike, which reportedly took place on Monday.
Turkey last month said it would allow US aircraft to use its southern Incirlik airbase to attack IS in Syria, potentially speeding up air strikes against the militants.